Re: Ivermectin
Posted: Wed Jan 05, 2022 6:00 pm
Must include Irish man William Campbell's fascinating lecture from a good number of years ago. Really interesting talk. Given at Trinity College. About the amazing substance that is Ivermectin. He was awarded the Nobel Prize for Ivermectin in 2015.
There is evidence coming out at the moment that Ivermectin is an immune modulator - it shows promising action against colorectal cancer and breast cancer. It's just amazing how it was found in that one soil sample. Among it's actions it works also as a protease and viral inhibitor.
I have seen another interesting story from Northern Ireland where soil taken from a grave in Boho, of a local priest. The soil was reputed locally to be a cure. It turns out that it is showing promise to deal with antibiotic resistance and combatting superbugs because of a unique strain of Streptomyces in it ! The earth is awesome. We have specific receptors in the human body that work with precise molecules just found in plants and natural substances that have no particular use to the plants or inert materials but are incredibly useful to us humans - this just regularly amazes me.
Here are proposed methods of action that could be possible with Ivermectin re Covid from Nature journal -
https://www.nature.com/articles/s41429-021-00491-6
A. Direct action on SARS-CoV-2
Level 1: Action on SARS-CoV-2 cell entry.
Level 2: Action on importin (IMP) superfamily.
Level 3: Action as an ionophore.
B. Action on host targets important for viral replication
Level 4: Action as an antiviral.
Level 5: Action on viral replication and assembly.
Level 6: Action on posttranslational processing of viral polyproteins.
Level 7: Action on karyopherin (KPNA/KPNB) receptors.
C. Action on host targets important for inflammation
Level 8: Action on interferon (INF) levels.
Level 9: Action on Toll-like receptors (TLRs).
Level 10: Action on nuclear factor-κB (NF-κB) pathway.
Level 11: Action on the JAK-STAT pathway, PAI-1, that could be involved with COVID-19 sequalae.
Level 12: Action on P21 activated kinase 1 (PAK1).
Level 13: Action on interleukin-6 (IL-6) levels.
Level 14: Action on allosteric modulation of P2X4 receptor.
Level 15: Action on high mobility group box 1 (HMGB1).
Level 16: Action as an immunomodulator on lung tissue and olfaction.
Level 17: Action as an anti-inflammatory.
D. Action on other host targets
Level 18: Action on plasmin and annexin A2.
Level 19: Action on CD 147 on the red blood cell (RBC).
Level 20: Action on mitochondrial ATP under hypoxia on cardiac function.
There is evidence coming out at the moment that Ivermectin is an immune modulator - it shows promising action against colorectal cancer and breast cancer. It's just amazing how it was found in that one soil sample. Among it's actions it works also as a protease and viral inhibitor.
I have seen another interesting story from Northern Ireland where soil taken from a grave in Boho, of a local priest. The soil was reputed locally to be a cure. It turns out that it is showing promise to deal with antibiotic resistance and combatting superbugs because of a unique strain of Streptomyces in it ! The earth is awesome. We have specific receptors in the human body that work with precise molecules just found in plants and natural substances that have no particular use to the plants or inert materials but are incredibly useful to us humans - this just regularly amazes me.
Here are proposed methods of action that could be possible with Ivermectin re Covid from Nature journal -
https://www.nature.com/articles/s41429-021-00491-6
A. Direct action on SARS-CoV-2
Level 1: Action on SARS-CoV-2 cell entry.
Level 2: Action on importin (IMP) superfamily.
Level 3: Action as an ionophore.
B. Action on host targets important for viral replication
Level 4: Action as an antiviral.
Level 5: Action on viral replication and assembly.
Level 6: Action on posttranslational processing of viral polyproteins.
Level 7: Action on karyopherin (KPNA/KPNB) receptors.
C. Action on host targets important for inflammation
Level 8: Action on interferon (INF) levels.
Level 9: Action on Toll-like receptors (TLRs).
Level 10: Action on nuclear factor-κB (NF-κB) pathway.
Level 11: Action on the JAK-STAT pathway, PAI-1, that could be involved with COVID-19 sequalae.
Level 12: Action on P21 activated kinase 1 (PAK1).
Level 13: Action on interleukin-6 (IL-6) levels.
Level 14: Action on allosteric modulation of P2X4 receptor.
Level 15: Action on high mobility group box 1 (HMGB1).
Level 16: Action as an immunomodulator on lung tissue and olfaction.
Level 17: Action as an anti-inflammatory.
D. Action on other host targets
Level 18: Action on plasmin and annexin A2.
Level 19: Action on CD 147 on the red blood cell (RBC).
Level 20: Action on mitochondrial ATP under hypoxia on cardiac function.